Morphologic analysis of epimorphin-transfected and normal MIC 216–Caco2 cocultures demonstrates effects on Caco2 cell morphology and spreading. Morphological features of Caco2 cells cocultured on top of confluent MIC 216 control and transfected cell lines. Phase-contrast microscopy shows living cocultures grown for 4 days in upper panels: (a) MIC 216 (b) pCEN (c) EpiS1 (d) EpiS2 (e) EpiAS1, and (f) EpiAS2; and cocultures grown for 10 days in lower panels: (g) pCEN (h) EpiS1 (i) EpiS2 (j) EpiAS1 (k) EpiAS2, and (l) MIC 216. Magnification: ×200.