ONYX-015: clinical data are encouraging
D Kirn, T Hermiston, F McCormick - Nature medicine, 1998 - nature.com
D Kirn, T Hermiston, F McCormick
Nature medicine, 1998•nature.comC33A 273 3 3 3 4 4 4 Hep 3B null 3 3 3 4 4 4 SW620 273 4 4 5 6 6 7 H1299 null 4 4 5 6 7 9
HT29 273 6 nt 7 8 nt 12 HS700T 249 6 nt 7 8 nt 12 MB231 280 7 7 8 9 9 12 DLD-1 241 7 nt
9 10 nt 14 D562 175 7 nt 9 10 nt 14 CPE, cytopathic effect; MOI, multiplicity-of-infection (ratio
of virus to cells at time of infection); nt, not tested; Ad5, wild-type adenovirus (serotype 5);
Wild-type D and ONYX-015 (dl1520) have identical E3 deletions (of genes E3 10.4,
14.5/14.7) but ONYX-015 is also deleted in the E1B, 55-kDa gene3. p53 mutations have …
HT29 273 6 nt 7 8 nt 12 HS700T 249 6 nt 7 8 nt 12 MB231 280 7 7 8 9 9 12 DLD-1 241 7 nt
9 10 nt 14 D562 175 7 nt 9 10 nt 14 CPE, cytopathic effect; MOI, multiplicity-of-infection (ratio
of virus to cells at time of infection); nt, not tested; Ad5, wild-type adenovirus (serotype 5);
Wild-type D and ONYX-015 (dl1520) have identical E3 deletions (of genes E3 10.4,
14.5/14.7) but ONYX-015 is also deleted in the E1B, 55-kDa gene3. p53 mutations have …
C33A 273 3 3 3 4 4 4 Hep 3B null 3 3 3 4 4 4 SW620 273 4 4 5 6 6 7 H1299 null 4 4 5 6 7 9 HT29 273 6 nt 7 8 nt 12 HS700T 249 6 nt 7 8 nt 12 MB231 280 7 7 8 9 9 12 DLD-1 241 7 nt 9 10 nt 14 D562 175 7 nt 9 10 nt 14
CPE, cytopathic effect; MOI, multiplicity-of-infection (ratio of virus to cells at time of infection); nt, not tested; Ad5, wild-type adenovirus (serotype 5); Wild-type D and ONYX-015 (dl1520) have identical E3 deletions (of genes E3 10.4, 14.5/14.7) but ONYX-015 is also deleted in the E1B, 55-kDa gene3. p53 mutations have been published previously2, 3.
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