Aging is associated with a progressive decline in T cell-mediated immune responses. Little
is known about the effect of aging on antigen presenting cells (APC). We have recently
reported an age-related decline in proliferative response of peripheral blood mononuclear
cells from elderly volunteers to Staphylococcus enterotoxin B (SEB). Since SEB-induced
stimulation of T cells is not restricted by major histocompatibility complex, experiments were
conducted in which T cells and APC from young and healthy elderly subjects were …