Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response
C Zhang, Y Cai, MT Adachi, S Oshiro, T Aso… - Journal of biological …, 2001 - ASBMB
Severe hyperhomocysteinemia is associated with endothelial cell injury that may contribute
to an increased incidence of thromboembolic disease. In this study, homocysteine induced
programmed cell death in human umbilical vein endothelial cells as measured by TdT-
mediated dUTP nick end labeling assay, DNA ladder formation, induction of caspase 3-like
activity, and cleavage of procaspase 3. Homocysteine-induced cell death was specific to
homocysteine, was not mediated by oxidative stress, and was mimicked by inducers of the …
to an increased incidence of thromboembolic disease. In this study, homocysteine induced
programmed cell death in human umbilical vein endothelial cells as measured by TdT-
mediated dUTP nick end labeling assay, DNA ladder formation, induction of caspase 3-like
activity, and cleavage of procaspase 3. Homocysteine-induced cell death was specific to
homocysteine, was not mediated by oxidative stress, and was mimicked by inducers of the …
