The synucleinopathies are a diverse group of neurodegenerative disorders that share a
common pathologic lesion composed of aggregates of insoluble α-synuclein protein in
selectively vulnerable populations of neurons and glia. Growing evidence links the formation
of abnormal filamentous aggregates to the onset and progression of clinical symptoms and
the degeneration of affected brain regions in neurodegenerative disorders. These disorders
may share an enigmatic symmetry, ie, missense mutations in the gene encoding for the …