Complete genomic screen in Parkinson disease: evidence for multiple genes
ContextThe relative contribution of genes vs environment in idiopathic Parkinson disease
(PD) is controversial. Although genetic studies have identified 2 genes in which mutations
cause rare single-gene variants of PD and observational studies have suggested a genetic
component, twin studies have suggested that little genetic contribution exists in the common
forms of PD. ObjectiveTo identify genetic risk factors for idiopathic PD. Design, Setting, and
ParticipantsGenetic linkage study conducted 1995-2000 in which a complete genomic …
(PD) is controversial. Although genetic studies have identified 2 genes in which mutations
cause rare single-gene variants of PD and observational studies have suggested a genetic
component, twin studies have suggested that little genetic contribution exists in the common
forms of PD. ObjectiveTo identify genetic risk factors for idiopathic PD. Design, Setting, and
ParticipantsGenetic linkage study conducted 1995-2000 in which a complete genomic …