Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
ContextThe human tau gene, which promotes assembly of neuronal microtubules, has been
associated with several rare neurologic diseases that clinically include parkinsonian
features. We recently observed linkage in idiopathic Parkinson disease (PD) to a region on
chromosome 17q21 that contains the tau gene. These factors make tau a good candidate for
investigation as a susceptibility gene for idiopathic PD, the most common form of the
disease. ObjectiveTo investigate whether the tau gene is involved in idiopathic PD. Design …
associated with several rare neurologic diseases that clinically include parkinsonian
features. We recently observed linkage in idiopathic Parkinson disease (PD) to a region on
chromosome 17q21 that contains the tau gene. These factors make tau a good candidate for
investigation as a susceptibility gene for idiopathic PD, the most common form of the
disease. ObjectiveTo investigate whether the tau gene is involved in idiopathic PD. Design …