Case‐control study of the extended tau gene haplotype in Parkinson's disease
DM Maraganore, DG Hernandez… - Annals of Neurology …, 2001 - Wiley Online Library
Annals of Neurology: Official Journal of the American Neurological …, 2001•Wiley Online Library
We investigated the association of Parkinson's disease with tau gene haplotypes. In a
sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we
observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype
(odds ratio= 1.5; 95% confidence interval: 0.98–2.23); however, the finding was not
statistically significant. The results remained similar after adjusting for the possible
misclassification of progressive supranuclear palsy patients as Parkinson's disease, but …
sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we
observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype
(odds ratio= 1.5; 95% confidence interval: 0.98–2.23); however, the finding was not
statistically significant. The results remained similar after adjusting for the possible
misclassification of progressive supranuclear palsy patients as Parkinson's disease, but …
Abstract
We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98–2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.
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