Genome-wide scan for Parkinson's disease: The Gene PD Study
AL DeStefano, LI Golbe, MH Mark, AM Lazzarini… - Neurology, 2001 - AAN Enterprises
Neurology, 2001•AAN Enterprises
Article abstract—A genome-wide scan for idiopathic PD in a sample of 113 PD-affected
sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1
(214 cM, lod= 1.20), 9 (136 cM, lod= 1.30), 10 (88 cM, lod= 1.07), and 16 (114 cM, lod=
0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and
torsion dystonia. Although no strong evidence for linkage was found for any locus, these
results may be of value in comparison with similar studies by others.
sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1
(214 cM, lod= 1.20), 9 (136 cM, lod= 1.30), 10 (88 cM, lod= 1.07), and 16 (114 cM, lod=
0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and
torsion dystonia. Although no strong evidence for linkage was found for any locus, these
results may be of value in comparison with similar studies by others.
Article abstract— A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
American Academy of Neurology