[HTML][HTML] Animal models of PD: pieces of the same puzzle?
Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The
etiology of PD is likely due, in part, to combinations of genetic susceptibilities and
environmental factors. In rare familial cases, PD is due to genetic mutations. A number of
new genetic and toxin models of PD and advances in older models are yielding important
new information about the pathogenesis of PD. This has prompted us to critically review the
current animal models for PD and discuss how these models may yield fresh insights into …
etiology of PD is likely due, in part, to combinations of genetic susceptibilities and
environmental factors. In rare familial cases, PD is due to genetic mutations. A number of
new genetic and toxin models of PD and advances in older models are yielding important
new information about the pathogenesis of PD. This has prompted us to critically review the
current animal models for PD and discuss how these models may yield fresh insights into …
Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in older models are yielding important new information about the pathogenesis of PD. This has prompted us to critically review the current animal models for PD and discuss how these models may yield fresh insights into the pathogenesis of PD, as well as new therapeutic opportunities.
cell.com