Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in
several age-related neurodegenerative disorders or animal models thereof, including
Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld–Jakob
disease, and α-synuclein disorders, such as Parkinson's disease and frontotemporal
dementia. Each of these neurodegenerative disorders is associated with aggregated
proteins in brain. However, the relationship among protein oxidation, protein aggregation …