[HTML][HTML] Hypoxia inhibits G1/S transition through regulation of p27 expression
LB Gardner, Q Li, MS Park, WM Flanagan… - Journal of biological …, 2001 - ASBMB
Mammalian cellular responses to hypoxia include adaptive metabolic changes and a G 1
cell cycle arrest. Although transcriptional regulation of metabolic genes by the hypoxia-
induced transcription factor (HIF-1) has been established, the mechanism for the hypoxia-
induced G 1 arrest is not known. By using genetically defined primary wild-type murine
embryo fibroblasts and those nullizygous for regulators of the G 1/S checkpoint, we
observed that the retinoblastoma protein is essential for the G 1/S hypoxia-induced …
cell cycle arrest. Although transcriptional regulation of metabolic genes by the hypoxia-
induced transcription factor (HIF-1) has been established, the mechanism for the hypoxia-
induced G 1 arrest is not known. By using genetically defined primary wild-type murine
embryo fibroblasts and those nullizygous for regulators of the G 1/S checkpoint, we
observed that the retinoblastoma protein is essential for the G 1/S hypoxia-induced …