[HTML][HTML] A human protein kinase Bγ with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
D Brodbeck, P Cron, BA Hemmings - Journal of Biological Chemistry, 1999 - ASBMB
We have cloned human protein kinase Bγ (PKBγ) and found that it contains two regulatory
phosphorylation sites, Thr 305 and Ser 472, which correspond to Thr 308 and Ser 473 of
PKBα. Thus it differs significantly from the previously published rat PKBγ. We have also
isolated a similar clone from a mouse cDNA library. In human tissues, PKBγ is widely
expressed as two transcripts. A mutational analysis of the two regulatory sites of human
PKBγ showed that phosphorylation of both sites, occurring in a phosphoinositide 3-kinase …
phosphorylation sites, Thr 305 and Ser 472, which correspond to Thr 308 and Ser 473 of
PKBα. Thus it differs significantly from the previously published rat PKBγ. We have also
isolated a similar clone from a mouse cDNA library. In human tissues, PKBγ is widely
expressed as two transcripts. A mutational analysis of the two regulatory sites of human
PKBγ showed that phosphorylation of both sites, occurring in a phosphoinositide 3-kinase …