[HTML][HTML] Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity
AN Vallejo, AR Nestel, M Schirmer, CM Weyand… - Journal of Biological …, 1998 - ASBMB
Changes in T cell populations and concomitant perturbation of T cell effector functions have
been postulated to account for many aging-related immune dysfunctions. Here, we report
that high frequencies of CD28 null CD4+ T cells were found in elderly individuals. Because
deviations in the function of these unusual CD4+ T cells might be directly related to CD28
deficiency, we examined the molecular basis for the loss of CD28 expression in CD4+ T
cells. In reporter gene bioassays, the minimal promoter of the CD28 gene was mapped to …
been postulated to account for many aging-related immune dysfunctions. Here, we report
that high frequencies of CD28 null CD4+ T cells were found in elderly individuals. Because
deviations in the function of these unusual CD4+ T cells might be directly related to CD28
deficiency, we examined the molecular basis for the loss of CD28 expression in CD4+ T
cells. In reporter gene bioassays, the minimal promoter of the CD28 gene was mapped to …
