Chronic activation of glomerular mitogen-activated protein kinases in Dahl salt-sensitive rats
A Hamaguchi, S Kim, Y Izumi… - Journal of the American …, 2000 - journals.lww.com
The in vivo role of mitogen-activated protein kinases (MAPK) in the development of
glomerular injury is poorly understood. In the present study, glomerular MAPK activities,
including extracellular signal-regulated kinases (ERK), c-Jun NH 2-terminal kinases (JNK),
and transcriptional factor, activator protein-1 (AP-1) were examined in glomerular injury of
salt-induced hypertensive rats. Six-week-old Dahl salt-sensitive (Dahl-S) and salt-resistant
(Dahl-R) rats were maintained on a high-salt (8.0% NaCl) diet for 1, 5, and 10 wk. In Dahl-S …
glomerular injury is poorly understood. In the present study, glomerular MAPK activities,
including extracellular signal-regulated kinases (ERK), c-Jun NH 2-terminal kinases (JNK),
and transcriptional factor, activator protein-1 (AP-1) were examined in glomerular injury of
salt-induced hypertensive rats. Six-week-old Dahl salt-sensitive (Dahl-S) and salt-resistant
(Dahl-R) rats were maintained on a high-salt (8.0% NaCl) diet for 1, 5, and 10 wk. In Dahl-S …