[HTML][HTML] Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation
JWM Creemers, JWHP van de Loo, E Plets… - Journal of Biological …, 2000 - ASBMB
Lymphoma proprotein convertase (LPC) is a subtilisin-like serine protease of the
mammalian proprotein convertase family. It is synthesized as an inactive precursor protein,
and propeptide cleavage occurs via intramolecular cleavage in the endoplasmic reticulum.
In contrast to other convertases like furin and proprotein convertase-1, propeptide cleavage
occurs slowly. Also, both a glycosylated and an unglycosylated precursor are detected. Here
we demonstrate that the unglycosylated precursor form of LPC is localized in the cytosol due …
mammalian proprotein convertase family. It is synthesized as an inactive precursor protein,
and propeptide cleavage occurs via intramolecular cleavage in the endoplasmic reticulum.
In contrast to other convertases like furin and proprotein convertase-1, propeptide cleavage
occurs slowly. Also, both a glycosylated and an unglycosylated precursor are detected. Here
we demonstrate that the unglycosylated precursor form of LPC is localized in the cytosol due …
