Tau protein isoforms, phosphorylation and role in neurodegenerative disorders

L Buée, T Bussière, V Buée-Scherrer… - Brain Research …, 2000 - Elsevier
Tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play an important role in the assembly of tubulin
monomers into microtubules to constitute the neuronal microtubules network. Microtubules
are involved in maintaining the cell shape and serve as tracks for axonal transport. Tau
proteins also establish some links between microtubules and other cytoskeletal elements or
proteins. Tau proteins are translated from a single gene located on chromosome 17. Their …