Adult renal stem cells and renal repair
JA Oliver - Current opinion in nephrology and hypertension, 2004 - journals.lww.com
JA Oliver
Current opinion in nephrology and hypertension, 2004•journals.lww.comWhile it remains unknown whether there is a stem cell in the adult kidney, characterization of
the cell populations involved in renal repair and misrepair is allowing a new understanding
of the mechanisms that are responsible for renal homeostasis. The most surprising results
suggest a very prominent role for cells exogenous to the kidney. Two recently published
transcription profiles of 'stemness' and the phenotype of pluripotent metanephric
mesenchymal cells may help in the search for adult renal stem cells.
the cell populations involved in renal repair and misrepair is allowing a new understanding
of the mechanisms that are responsible for renal homeostasis. The most surprising results
suggest a very prominent role for cells exogenous to the kidney. Two recently published
transcription profiles of 'stemness' and the phenotype of pluripotent metanephric
mesenchymal cells may help in the search for adult renal stem cells.
Summary
While it remains unknown whether there is a stem cell in the adult kidney, characterization of the cell populations involved in renal repair and misrepair is allowing a new understanding of the mechanisms that are responsible for renal homeostasis. The most surprising results suggest a very prominent role for cells exogenous to the kidney. Two recently published transcription profiles of ‘stemness’ and the phenotype of pluripotent metanephric mesenchymal cells may help in the search for adult renal stem cells.
Lippincott Williams & Wilkins