Identification of renal progenitor-like tubular cells that participate in the regeneration processes of the kidney
A Maeshima, S Yamashita… - Journal of the American …, 2003 - journals.lww.com
The present study was conducted to explore renal progenitor-like cells that are actively
engaged in tubular regeneration after injury. For addressing this issue, the existence of label-
retaining cells (LRC; slow-cycling cells) in normal rat kidneys by in vivo bromodeoxyuridine
(BrdU) labeling was examined. LRC were scattering among renal epithelial tubular cells of
normal rat kidneys. During the recovery after renal ischemia, LRC underwent cell division
and most of them became positive for proliferating cell nuclear antigen. In contrast …
engaged in tubular regeneration after injury. For addressing this issue, the existence of label-
retaining cells (LRC; slow-cycling cells) in normal rat kidneys by in vivo bromodeoxyuridine
(BrdU) labeling was examined. LRC were scattering among renal epithelial tubular cells of
normal rat kidneys. During the recovery after renal ischemia, LRC underwent cell division
and most of them became positive for proliferating cell nuclear antigen. In contrast …