Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism
HT Zhang, AM Crissman, NR Dorairaj… - …, 2000 - Elsevier
Rolipram, a selective inhibitor of type 4 cyclic AMP phosphodiesterase (PDE4), completely
reversed the amnesic effects of MK-801 on working and reference memory (F [4, 64]= 11.10;
p<. 0001 and F [4, 64]= 2.53; p<. 05, respectively) at doses of 0.01–0.1 mg/kg in the radial-
arm maze task. Similar antagonism by rolipram of the effects of MK-801 was observed on
inhibitory avoidance behavior (F [3, 35]= 190.8; p<. 0001). In vitro evidence suggests that an
increase in cAMP concentrations may mediate the observed behavioral effects of rolipram …
reversed the amnesic effects of MK-801 on working and reference memory (F [4, 64]= 11.10;
p<. 0001 and F [4, 64]= 2.53; p<. 05, respectively) at doses of 0.01–0.1 mg/kg in the radial-
arm maze task. Similar antagonism by rolipram of the effects of MK-801 was observed on
inhibitory avoidance behavior (F [3, 35]= 190.8; p<. 0001). In vitro evidence suggests that an
increase in cAMP concentrations may mediate the observed behavioral effects of rolipram …
