Caspase-3 inhibitor rescues N-methyl-N-nitrosourea-induced retinal degeneration in Sprague–Dawley rats
K Yoshizawa, J Yang, H Senzaki, Y Uemura… - Experimental eye …, 2000 - Elsevier
The effect of a caspase-3 inhibitor on N-methyl-N-nitrosourea (MNU)-induced retinal
degeneration was investigated. Sixty mgkg− 1MNU was given intraperitoneally to 50 day old
female Sprague–Dawley rats, and 4000ng Ac-DEVD-CHO, a caspase-3 inhibitor, was
injected intravitreally twice at 0 and 10hr after MNU. In both peripheral and central retina, an
apoptotic index of the photoreceptor cells 24hr after MNU treatment was calculated by
TUNEL labeling, and retinal damage 7 days after MNU treatment was evaluated from retinal …
degeneration was investigated. Sixty mgkg− 1MNU was given intraperitoneally to 50 day old
female Sprague–Dawley rats, and 4000ng Ac-DEVD-CHO, a caspase-3 inhibitor, was
injected intravitreally twice at 0 and 10hr after MNU. In both peripheral and central retina, an
apoptotic index of the photoreceptor cells 24hr after MNU treatment was calculated by
TUNEL labeling, and retinal damage 7 days after MNU treatment was evaluated from retinal …
