Are mechanical and cold allodynia in mononeuropathic and arthritic rats relieved by systemic treatment with calcitonin or guanethidine?
The putative antinociceptive action of guanethidine and calcitonin systemically injected has
been compared in 2 rat models of persistant experimental pain: Freund's adjuvant-induced
arthritis (n= 29) and mononeuropathy induced by 4 loose ligatures around the sciatic nerve
(n= 24). Guanethidine (30 mg/kg, iv) and calcitonin (0.125 mg, sc) were injected once a day
over 1 week, when hyperalgesia was fully developed. The antinociceptive action was
gauged using nociceptive tests based on mechanical or cold stimuli (vocalization threshold …
been compared in 2 rat models of persistant experimental pain: Freund's adjuvant-induced
arthritis (n= 29) and mononeuropathy induced by 4 loose ligatures around the sciatic nerve
(n= 24). Guanethidine (30 mg/kg, iv) and calcitonin (0.125 mg, sc) were injected once a day
over 1 week, when hyperalgesia was fully developed. The antinociceptive action was
gauged using nociceptive tests based on mechanical or cold stimuli (vocalization threshold …