Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells
E Razin, ZC Zhang, H Nechushtan, S Frenkel… - Journal of Biological …, 1999 - ASBMB
Microphthalmia (mi) is a transcription factor that plays a major role in the regulation of growth
and function in mast cells and melanocytes. Association ofmi with other proteins is a critical
step in the regulation of mi-mediated transcriptional activation. We found protein kinase C-
interacting protein 1 (PKCI) specifically associated withmi in yeast two-hybrid screening.
Immunoprecipitation ofmi from quiescent rat basophilic leukemic cells or mouse
melanocytes resulted in the specific co-immunoprecipitation of PKCI. This association was …
and function in mast cells and melanocytes. Association ofmi with other proteins is a critical
step in the regulation of mi-mediated transcriptional activation. We found protein kinase C-
interacting protein 1 (PKCI) specifically associated withmi in yeast two-hybrid screening.
Immunoprecipitation ofmi from quiescent rat basophilic leukemic cells or mouse
melanocytes resulted in the specific co-immunoprecipitation of PKCI. This association was …
