[HTML][HTML] The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ
Mechanisms of development, 2001•Elsevier
During brain development, Pax6 is expressed in specific regions of the diencephalon
including secretory cells of the subcommissural organ (SCO), a circumventricular organ at
the forebrain–midbrain boundary that originates from the pretectal dorsal midline
neuroepithelial cells beneath the posterior commissure (PC). Homozygous small eye
(Sey/Sey) mice lack functional Pax6 protein and fail to develop the SCO, a normal PC and
the pineal gland. Small eye heterozygotes (Sey/+) show defective development of the SCO's …
including secretory cells of the subcommissural organ (SCO), a circumventricular organ at
the forebrain–midbrain boundary that originates from the pretectal dorsal midline
neuroepithelial cells beneath the posterior commissure (PC). Homozygous small eye
(Sey/Sey) mice lack functional Pax6 protein and fail to develop the SCO, a normal PC and
the pineal gland. Small eye heterozygotes (Sey/+) show defective development of the SCO's …
During brain development, Pax6 is expressed in specific regions of the diencephalon including secretory cells of the subcommissural organ (SCO), a circumventricular organ at the forebrain–midbrain boundary that originates from the pretectal dorsal midline neuroepithelial cells beneath the posterior commissure (PC). Homozygous small eye (Sey/Sey) mice lack functional Pax6 protein and fail to develop the SCO, a normal PC and the pineal gland. Small eye heterozygotes (Sey/+) show defective development of the SCO's basal processes which normally penetrate the PC, indicating that normal development of the gland requires normal Pax6 gene-dosage. A correlation between the defects of SCO formation and altered R- and OB-cadherin expression patterns in the SCO is observed in mutants suggesting a role for cadherins in SCO development.
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