Mast cells are not only necessary for allergic reactions, but recent findings indicate that they
are also involved in a variety of neuroinflammatory diseases, especially those worsened by
stress. In these cases, mast cells appear to be activated through their Fc receptors by
immunoglobulins other than IgE, as well as by anaphylatoxins, neuropeptides and cytokines
to secrete mediators selectively without overt degranulation. These facts can help us better
understand a variety of sterile inflammatory conditions, such as multiple sclerosis (MS) …