Molecular assembly of cystic fibrosis transmembrane conductance regulator in plasma membrane
C Li, K Roy, K Dandridge, AP Naren - Journal of Biological Chemistry, 2004 - ASBMB
Based on electrophysiological measurements, it has been argued that the active form of
cystic fibrosis trans-membrane conductance regulator (CFTR) Cl-channel is a multimer. It
has also been demonstrated that this multimerization is likely due to PDZ domain-interacting
partners. Here we demonstrate that although CFTR in vitro can self-associate into multimers,
which depends on PDZ-based interactions, this may not be the case in cell membrane.
Using chemical cross-linking, we demonstrated that CFTR exists as a higher order complex …
cystic fibrosis trans-membrane conductance regulator (CFTR) Cl-channel is a multimer. It
has also been demonstrated that this multimerization is likely due to PDZ domain-interacting
partners. Here we demonstrate that although CFTR in vitro can self-associate into multimers,
which depends on PDZ-based interactions, this may not be the case in cell membrane.
Using chemical cross-linking, we demonstrated that CFTR exists as a higher order complex …
