[HTML][HTML] Exercise stimulates Pgc-1α transcription in skeletal muscle through activation of the p38 MAPK pathway
T Akimoto, SC Pohnert, P Li, M Zhang, C Gumbs… - Journal of Biological …, 2005 - ASBMB
Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) promotes
mitochondrial biogenesis and slow fiber formation in skeletal muscle. We hypothesized that
activation of the p38 mitogen-activated protein kinase (MAPK) pathway in response to
increased muscle activity stimulated Pgc-1α gene transcription as part of the mechanisms for
skeletal muscle adaptation. Here we report that a single bout of voluntary running induced a
transient increase of Pgc-1α mRNA expression in mouse plantaris muscle, concurrent with …
mitochondrial biogenesis and slow fiber formation in skeletal muscle. We hypothesized that
activation of the p38 mitogen-activated protein kinase (MAPK) pathway in response to
increased muscle activity stimulated Pgc-1α gene transcription as part of the mechanisms for
skeletal muscle adaptation. Here we report that a single bout of voluntary running induced a
transient increase of Pgc-1α mRNA expression in mouse plantaris muscle, concurrent with …