[HTML][HTML] Multiple Dual Specificity Protein Tyrosine Phosphatases Are Expressed and Regulated Differentially in Liver Cell Lines (∗)
SP Kwak, JE Dixon - Journal of Biological Chemistry, 1995 - ASBMB
An emerging subclass of protein-tyrosine phosphatases (PTPases) exhibits sequence
identity to the vaccinia H-1 (VH-1) gene product. These VH-1-like PTPases possess the
canonical HCXAGXXR (S/T) sequence common to all PTPases, but unlike other PTPases
they exhibit dual catalytic activity toward phosphotyrosine and nearby phosphothreonine
residues in substrate proteins. We have isolated a novel VH-1-like PTPase, hVH-3, from the
human placenta and compared various aspects of its expression with previously isolated …
identity to the vaccinia H-1 (VH-1) gene product. These VH-1-like PTPases possess the
canonical HCXAGXXR (S/T) sequence common to all PTPases, but unlike other PTPases
they exhibit dual catalytic activity toward phosphotyrosine and nearby phosphothreonine
residues in substrate proteins. We have isolated a novel VH-1-like PTPase, hVH-3, from the
human placenta and compared various aspects of its expression with previously isolated …