HIV-1 immunopathogenesis: how good interferon turns bad
JP Herbeuval, GM Shearer - Clinical immunology, 2007 - Elsevier
The hallmark of acquired immunodeficiency syndrome (AIDS) is the progressive loss of
CD4+ T cells that results from infection with human immunodeficiency virus type-1 (HIV-1).
Despite 25 years of AIDS research, questions remain concerning the mechanisms
responsible for HIV-induced CD4+ T cell depletion. Here we briefly review the in vitro and in
vivo literature concerning the protective role of interferon-alpha (IFN-α) in HIV/AIDS. We then
develop a laboratory-and clinically supported model of CD4+ T cell apoptosis in which either …
CD4+ T cells that results from infection with human immunodeficiency virus type-1 (HIV-1).
Despite 25 years of AIDS research, questions remain concerning the mechanisms
responsible for HIV-induced CD4+ T cell depletion. Here we briefly review the in vitro and in
vivo literature concerning the protective role of interferon-alpha (IFN-α) in HIV/AIDS. We then
develop a laboratory-and clinically supported model of CD4+ T cell apoptosis in which either …
