Increased number of peripheral blood CD34+ cells in lithium‐treated patients
A Ballin, D Lehman, P Sirota… - British journal of …, 1998 - Wiley Online Library
A Ballin, D Lehman, P Sirota, U Litvinjuk, D Meytes
British journal of haematology, 1998•Wiley Online LibraryEight adult patients with bipolar disorder were prospectively examined to find whether
lithium carbonate increased their peripheral blood CD34+ haemopoietic stem cells.
Following lithium therapy for 3–4 weeks their neutrophil counts increased by a mean of
88%(from 4625±1350× 109/l, mean±SD pretreatment, to a peak of 8300±3910× 109/l).
Concommitantly, there was a significant increment in their CD34+ cells (from 0.11±0.01% to
a peak of 0.18±0.08%). There was a significant correlation between the rise in neutrophil …
lithium carbonate increased their peripheral blood CD34+ haemopoietic stem cells.
Following lithium therapy for 3–4 weeks their neutrophil counts increased by a mean of
88%(from 4625±1350× 109/l, mean±SD pretreatment, to a peak of 8300±3910× 109/l).
Concommitantly, there was a significant increment in their CD34+ cells (from 0.11±0.01% to
a peak of 0.18±0.08%). There was a significant correlation between the rise in neutrophil …
Eight adult patients with bipolar disorder were prospectively examined to find whether lithium carbonate increased their peripheral blood CD34+ haemopoietic stem cells. Following lithium therapy for 3–4 weeks their neutrophil counts increased by a mean of 88% (from 4625 ± 1350 × 109/l, mean ± SD pretreatment, to a peak of 8300 ± 3910 × 109/l). Concommitantly, there was a significant increment in their CD34+ cells (from 0.11 ± 0.01% to a peak of 0.18 ± 0.08%). There was a significant correlation between the rise in neutrophil count and that of the CD34+ cells (r = 0.795, P = 0.019). Lithium therapy may be used to mobilize peripheral blood CD34+ cells for marrow transplantation.
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