Upregulation of stem cell genes in multidrug resistant K562 leukemia cells
G Lehne, UH Grasmo-Wendler, JM Berner… - Leukemia research, 2009 - Elsevier
The transmembrane transporter P-glycoprotein (P-gp) encoded by ABCB1, is one major
cause for multidrug resistance (MDR). We compared the genomic profile and gene
expression pattern of the P-gp positive K562VCR cells with parental P-gp negative K562wt
cells. In K562VCR array CGH revealed amplification of ABCB1, ABCB4, ABCB5 and
SEMA3D, whereas expression microarrays demonstrated upregulation of stem cell genes
(eg KIT and HOXB4), anti-apoptotic genes (eg IGF1R and CCNG1), and downregulation of …
cause for multidrug resistance (MDR). We compared the genomic profile and gene
expression pattern of the P-gp positive K562VCR cells with parental P-gp negative K562wt
cells. In K562VCR array CGH revealed amplification of ABCB1, ABCB4, ABCB5 and
SEMA3D, whereas expression microarrays demonstrated upregulation of stem cell genes
(eg KIT and HOXB4), anti-apoptotic genes (eg IGF1R and CCNG1), and downregulation of …