The bone marrow vascular niche: home of HSC differentiation and mobilization
The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated
sinusoidal vessels whose integrity is maintained and supported by surrounding
hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow
vasculature provides not only a conduit for mature hematopoietic cells to the peripheral
circulation but also a site where hematopoietic progenitors, especially megakaryocytes,
differentiate and set the stage for full reconstitution of hematopoiesis.
sinusoidal vessels whose integrity is maintained and supported by surrounding
hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow
vasculature provides not only a conduit for mature hematopoietic cells to the peripheral
circulation but also a site where hematopoietic progenitors, especially megakaryocytes,
differentiate and set the stage for full reconstitution of hematopoiesis.
The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.
American Physiological Society