[HTML][HTML] Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells
Previous studies have indicated an intimate linkage between gap junction and adherens
junction formation. It was suggested this could reflect the close membrane-membrane
apposition required for junction formation. In NIH3T3 cells, we observed the colocalization of
connexin43 (Cx43α1) gap junction protein with N-cadherin, p120, and other N-cadherin-
associated proteins at regions of cell-cell contact. We also found that Cx43α1, N-cadherin,
and N-cadherin-associated proteins were coimmunoprecipitated by antibodies to either …
junction formation. It was suggested this could reflect the close membrane-membrane
apposition required for junction formation. In NIH3T3 cells, we observed the colocalization of
connexin43 (Cx43α1) gap junction protein with N-cadherin, p120, and other N-cadherin-
associated proteins at regions of cell-cell contact. We also found that Cx43α1, N-cadherin,
and N-cadherin-associated proteins were coimmunoprecipitated by antibodies to either …