Maximizing CD8+ T cell responses elicited by peptide vaccines containing CpG oligodeoxynucleotides
JN Kochenderfer, CD Chien, JL Simpson, RE Gress - Clinical Immunology, 2007 - Elsevier
We assessed the ability of several factors to increase the size of tumor-antigen-specific
CD8+ T cell responses elicited by vaccines incorporating peptides and CpG-containing
oligodeoxynucleotides (CpG). Neither granulocyte-macrophage colony-stimulating factor
(GM-CSF) nor an immunogenic MHC class II-presented “helper” peptide increased the size
of epitope-specific CD8+ T cell responses elicited by peptide+ CpG-containing vaccines. In
contrast, low-dose subcutaneous interleukin (IL)-2 dramatically increased the size of splenic …
CD8+ T cell responses elicited by vaccines incorporating peptides and CpG-containing
oligodeoxynucleotides (CpG). Neither granulocyte-macrophage colony-stimulating factor
(GM-CSF) nor an immunogenic MHC class II-presented “helper” peptide increased the size
of epitope-specific CD8+ T cell responses elicited by peptide+ CpG-containing vaccines. In
contrast, low-dose subcutaneous interleukin (IL)-2 dramatically increased the size of splenic …