[HTML][HTML] Regulation of Platelet-derived Growth Factor-A Chain by Krüppel-like Factor 5*: NEW PATHWAY OF COOPERATIVE ACTIVATION WITH NUCLEAR FACTOR …
K Aizawa, T Suzuki, N Kada, A Ishihara… - Journal of Biological …, 2004 - ASBMB
The transcription factor Krüppel-like factor 5 (KLF5) and its genetically downstream target
gene platelet-derived growth factor-A (PDGF-A) chain are key factors in regulation of
cardiovascular remodeling in response to stress. We show that KLF5 mediates a novel
distinct delayed persistent induction of PDGF-A chain in response to the model agonist,
phorbol ester, through a cis-element previously shown to mediate phorbol ester induction on
to PDGF-A chain through the early growth response factor (Egr-1). Interestingly, the nuclear …
gene platelet-derived growth factor-A (PDGF-A) chain are key factors in regulation of
cardiovascular remodeling in response to stress. We show that KLF5 mediates a novel
distinct delayed persistent induction of PDGF-A chain in response to the model agonist,
phorbol ester, through a cis-element previously shown to mediate phorbol ester induction on
to PDGF-A chain through the early growth response factor (Egr-1). Interestingly, the nuclear …