Functional properties and differential neuromodulation of Nav1. 6 channels
Y Chen, HY Frank, EM Sharp, D Beacham… - Molecular and Cellular …, 2008 - Elsevier
The voltage-gated sodium channel Nav1. 6 plays unique roles in the nervous system, but its
functional properties and neuromodulation are not as well established as for NaV1. 2
channels. We found no significant differences in voltage-dependent activation or fast
inactivation between NaV1. 6 and NaV1. 2 channels expressed in non-excitable cells. In
contrast, the voltage dependence of slow inactivation was more positive for Nav1. 6
channels, they conducted substantially larger persistent sodium currents than Nav1. 2 …
functional properties and neuromodulation are not as well established as for NaV1. 2
channels. We found no significant differences in voltage-dependent activation or fast
inactivation between NaV1. 6 and NaV1. 2 channels expressed in non-excitable cells. In
contrast, the voltage dependence of slow inactivation was more positive for Nav1. 6
channels, they conducted substantially larger persistent sodium currents than Nav1. 2 …