[HTML][HTML] The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor-α and fas ligand but does not suppress expression of …
PS Koh, GC Hughes, GR Faulkner, WW Keeble… - Experimental …, 1999 - Elsevier
Exposure of hematopoietic progenitor cells (HPC) from mice and humans with Fanconi
anemia group C (FAC) to interferon-γ (IFN-γ) or tumor necrosis factor-α (TNF-α) at doses too
low to inhibit growth of normal HPC induces profound apoptotic responses. Because the IFN-
γ hypersensitivity of cells lacking the FAC protein is mediated, in part, through priming of the
Fas pathway, and because several other members of this family are capable of inducing
apoptosis either alone or in concert with each other, we tested the hypothesis that IFN-γ …
anemia group C (FAC) to interferon-γ (IFN-γ) or tumor necrosis factor-α (TNF-α) at doses too
low to inhibit growth of normal HPC induces profound apoptotic responses. Because the IFN-
γ hypersensitivity of cells lacking the FAC protein is mediated, in part, through priming of the
Fas pathway, and because several other members of this family are capable of inducing
apoptosis either alone or in concert with each other, we tested the hypothesis that IFN-γ …
