Selective elimination of autoreactive T cells in vivo by the regulatory T cells
How regulatory T cells (Treg) control autoreactive T cells has not been analyzed in animals
with a normal T cell repertoire. Using endogenous viral superantigens (VSAg) as the primary
self antigens and mice with the Scurfy mutation of FoxP3, we show here that the Treg defect
causes preferential accumulation of autoreactive T cells. Interestingly, in the Scurfy mice, the
proliferation of VSAg-reactive T cells was no more vigorous than that of non-VSAg-reactive T
cells, which indicated that the preferential accumulation is not due to preferential …
with a normal T cell repertoire. Using endogenous viral superantigens (VSAg) as the primary
self antigens and mice with the Scurfy mutation of FoxP3, we show here that the Treg defect
causes preferential accumulation of autoreactive T cells. Interestingly, in the Scurfy mice, the
proliferation of VSAg-reactive T cells was no more vigorous than that of non-VSAg-reactive T
cells, which indicated that the preferential accumulation is not due to preferential …
