Tissue specific mutagenic and carcinogenic responses in NER defective mouse models
SWP Wijnhoven, EM Hoogervorst, H de Waard… - Mutation Research …, 2007 - Elsevier
Several mouse models with defects in genes encoding components of the nucleotide
excision repair (NER) pathway have been developed. In NER two different sub-pathways
are known, ie transcription-coupled repair (TC-NER) and global-genome repair (GG-NER).
A defect in one particular NER protein can lead to a (partial) defect in GG-NER, TC-NER or
both. GG-NER defects in mice predispose to cancer, both spontaneous as well as UV-
induced. As such these models (Xpa, Xpc and Xpe) recapitulate the human xeroderma …
excision repair (NER) pathway have been developed. In NER two different sub-pathways
are known, ie transcription-coupled repair (TC-NER) and global-genome repair (GG-NER).
A defect in one particular NER protein can lead to a (partial) defect in GG-NER, TC-NER or
both. GG-NER defects in mice predispose to cancer, both spontaneous as well as UV-
induced. As such these models (Xpa, Xpc and Xpe) recapitulate the human xeroderma …
