[HTML][HTML] Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis
Ubiquinone (coenzyme Q or Q) is a lipid that functions in the electron transport chain in the
inner mitochondrial membrane of eukaryotes and the plasma membrane of prokaryotes. Q-
deficient mutants of Saccharomyces cerevisiae harbor defects in one of eight COQ genes
(coq1–coq8) and are unable to grow on nonfermentable carbon sources. The biosynthesis
of Q involves two separate O-methylation steps. In yeast, the first O-methylation utilizes 3, 4-
dihydroxy-5-hexaprenylbenzoic acid as a substrate and is thought to be catalyzed by …
inner mitochondrial membrane of eukaryotes and the plasma membrane of prokaryotes. Q-
deficient mutants of Saccharomyces cerevisiae harbor defects in one of eight COQ genes
(coq1–coq8) and are unable to grow on nonfermentable carbon sources. The biosynthesis
of Q involves two separate O-methylation steps. In yeast, the first O-methylation utilizes 3, 4-
dihydroxy-5-hexaprenylbenzoic acid as a substrate and is thought to be catalyzed by …