Gadd45 in the response of hematopoietic cells to genotoxic stress
DA Liebermann, B Hoffman - Blood Cells, Molecules, and Diseases, 2007 - Elsevier
Gadd45 genes have been implicated in stress signaling in response to physiological or
environmental stressors, which results in either cell cycle arrest, DNA repair, cell survival
and senescence, or apoptosis. Evidence accumulated implies that Gadd45 proteins function
as stress sensors is mediated by a complex interplay of physical interactions with other
cellular proteins that are implicated in cell cycle regulation and the response of cells to
stress. These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response …
environmental stressors, which results in either cell cycle arrest, DNA repair, cell survival
and senescence, or apoptosis. Evidence accumulated implies that Gadd45 proteins function
as stress sensors is mediated by a complex interplay of physical interactions with other
cellular proteins that are implicated in cell cycle regulation and the response of cells to
stress. These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response …
