[HTML][HTML] Cell survival and a Gadd45-factor deficiency
A Amanullah, N Azam, A Balliet, C Hollander… - Nature, 2003 - nature.com
A Amanullah, N Azam, A Balliet, C Hollander, B Hoffman, A Fornace Jr, D Liebermann
Nature, 2003•nature.comTumour-necrosis factor-α (TNF-α) is an important protein that regulates inflammation,
immunity, cell survival and cell death in response to infection or chronic stress,,,,. De Smaele
et al. report that the gene encoding an inducible cellular factor, Gadd45β (for'growth arrest
and DNA damage'), is essential for promoting TNF-α-mediated cell survival. However, we
show here that neither TNF-α signalling nor cell survival is affected in mice lacking gadd45
β, a fact which demonstrates that genes other than gadd45 β (refs,) might regulate cell …
immunity, cell survival and cell death in response to infection or chronic stress,,,,. De Smaele
et al. report that the gene encoding an inducible cellular factor, Gadd45β (for'growth arrest
and DNA damage'), is essential for promoting TNF-α-mediated cell survival. However, we
show here that neither TNF-α signalling nor cell survival is affected in mice lacking gadd45
β, a fact which demonstrates that genes other than gadd45 β (refs,) might regulate cell …
Abstract
Tumour-necrosis factor-α (TNF-α) is an important protein that regulates inflammation, immunity, cell survival and cell death in response to infection or chronic stress,,,,. De Smaele et al. report that the gene encoding an inducible cellular factor, Gadd45β (for 'growth arrest and DNA damage'), is essential for promoting TNF-α-mediated cell survival. However, we show here that neither TNF-α signalling nor cell survival is affected in mice lacking gadd45β, a fact which demonstrates that genes other than gadd45β (refs , ) might regulate cell survival in response to TNF-α.
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