Role of apoptosis for mouse liver growth regulation and tumor promotion: comparative analysis of mice with high (C3H/He) and low (C57Bl/6J) cancer susceptibility
W Bursch, B Grasl-Kraupp, U Wastl, K Hufnagl… - Toxicology letters, 2004 - Elsevier
Apoptosis constitutes one of the organisms defense lines against cancer. We investigated
whether failure of apoptosis may be concurrently causative for the high cancer susceptibility
in C3H/He as compared to C57BL/6J mice (low cancer susceptibility). First, in short-term in
vivo experiments (7–21 days), mouse liver growth (C3H/He, C57BL/6J) was induced by
administration of phenobarbital (PB; 2 days 500ppm+ 5 days 750ppm via the food) or
nafenopin (NAF; 7 days 500ppm via the food), cessation of PB or NAF treatment served to …
whether failure of apoptosis may be concurrently causative for the high cancer susceptibility
in C3H/He as compared to C57BL/6J mice (low cancer susceptibility). First, in short-term in
vivo experiments (7–21 days), mouse liver growth (C3H/He, C57BL/6J) was induced by
administration of phenobarbital (PB; 2 days 500ppm+ 5 days 750ppm via the food) or
nafenopin (NAF; 7 days 500ppm via the food), cessation of PB or NAF treatment served to …
