[HTML][HTML] Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell …
EJ Scheinman, O Avni - Journal of biological chemistry, 2009 - ASBMB
GATA3 is a critical transcription factor for many developmental processes. During T helper
(Th) cell differentiation, GATA3 induces the Th2 and suppresses the Th1 pathway.
Stimulation of the T cell receptor (TCR) of naive Th cells in the presence of interleukin 4 (IL-
4) induces robust expression of GATA3; however, it is unclear where these signals integrate.
Gata3 encodes two transcripts that differ in their alternative, untranslated first exons. We
show here the involvement of the TCR-inducible transcription factor NFAT1 in the …
(Th) cell differentiation, GATA3 induces the Th2 and suppresses the Th1 pathway.
Stimulation of the T cell receptor (TCR) of naive Th cells in the presence of interleukin 4 (IL-
4) induces robust expression of GATA3; however, it is unclear where these signals integrate.
Gata3 encodes two transcripts that differ in their alternative, untranslated first exons. We
show here the involvement of the TCR-inducible transcription factor NFAT1 in the …
