IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU. 1
S Hadjur, L Bruno, A Hertweck, BS Cobb, B Taylor… - Immunology letters, 2009 - Elsevier
Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into
regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen.
A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage
choice by cytokines and transcription factors that are expressed in alternative lineages. For
example, TGFβ induces the de novo expression of the Treg cell signature transcription factor
Foxp3, but iTreg differentiation is blocked by high concentrations of the Th2 cytokine IL4 …
regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen.
A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage
choice by cytokines and transcription factors that are expressed in alternative lineages. For
example, TGFβ induces the de novo expression of the Treg cell signature transcription factor
Foxp3, but iTreg differentiation is blocked by high concentrations of the Th2 cytokine IL4 …
