Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the …
J Bakker, R Grover, A McLuckie, L Holzapfel… - Critical care …, 2004 - journals.lww.com
Objective To assess the safety and efficacy of the nitric oxide synthase inhibitor 546C88 in
patients with septic shock. The predefined primary efficacy objective was resolution of shock,
defined as a mean arterial pressure≥ 70 mm Hg in the absence of both conventional
vasopressors and study drug, determined at the end of the 72-hr treatment period. Design
patients with septic shock. The predefined primary efficacy objective was resolution of shock,
defined as a mean arterial pressure≥ 70 mm Hg in the absence of both conventional
vasopressors and study drug, determined at the end of the 72-hr treatment period. Design
