Expression of αIIbβ3 Integrin (GPIIb-IIIa) in Myeloid Cell Lines and Normal CD34+/CD33+ Bone Marrow Cells
CD Wall, PB Conley, J Armendariz-Borunda… - Blood Cells, Molecules …, 1997 - Elsevier
Regulation of myeloid cell proliferation and differentiation in the bone marrow is mediated, in
part, by the interaction of integrins on early myeloid cells with the extracellular matrix
proteins secreted by stromal cells. To further define adhesive protein receptors of early
myeloid cells, we examined the expression of the integrin GPIIb-IIIa (αIIbβ3) in leukemic cell
lines KG-1a, KG-1, and HL-60, that represent early stages of myeloid differentiation. All three
cell lines expressed surface GPIIb-IIIa as measured by flow cytometry and by binding of125I …
part, by the interaction of integrins on early myeloid cells with the extracellular matrix
proteins secreted by stromal cells. To further define adhesive protein receptors of early
myeloid cells, we examined the expression of the integrin GPIIb-IIIa (αIIbβ3) in leukemic cell
lines KG-1a, KG-1, and HL-60, that represent early stages of myeloid differentiation. All three
cell lines expressed surface GPIIb-IIIa as measured by flow cytometry and by binding of125I …
