BACKGROUND: Nitric oxide (NO) seems to play an important pathophysiologic role in
modulating the systemic changes associated with anaphylaxis. Even if some effects of NO
may be protective, animal models of anaphylaxis have shown that the summation effects of
NO are deleterious, resulting in hypotension and loss of intravascular volume. There are no
studies of NO production during anaphylaxis in humans. OBJECTIVES: To measure the
level of exhaled NO during anaphylaxis induced by bee venom cluster immunotherapy in a …