Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression
Expression of inducible nitric-oxide (NO) synthase (iNOS) and" high-output" production of
NO by macrophages mediates many cytotoxic actions of these immune cells. However,
macrophages have also been shown to express a constitutive NOS isoform, the function of
which remains obscure. Herein, bone marrow-derived macrophages (BMDMØs) from wild-
type and endothelial NOS (eNOS) knock-out (KO) mice have been used to assess the role of
this constitutive NOS isoform in the regulation of macrophage activation. BMDMØs from …
NO by macrophages mediates many cytotoxic actions of these immune cells. However,
macrophages have also been shown to express a constitutive NOS isoform, the function of
which remains obscure. Herein, bone marrow-derived macrophages (BMDMØs) from wild-
type and endothelial NOS (eNOS) knock-out (KO) mice have been used to assess the role of
this constitutive NOS isoform in the regulation of macrophage activation. BMDMØs from …
