[HTML][HTML] Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-α: a novel feedback mechanism regulating cell death
S Bulotta, R Barsacchi, D Rotiroti, N Borgese… - Journal of Biological …, 2001 - ASBMB
Cell death via apoptosis induced by tumor necrosis factor-α (TNF-α) plays an important role
in many physiological and pathological conditions. The signal transduction pathway
activated by this cytokine is known to be regulated by several intracellular messengers. In
particular, in many systems nitric oxide (NO) has been shown to protect cells from TNF-α-
induced apoptosis. However, whether NO can be generated by the cytokine to down-
regulate its own apoptotic program has never been studied. We have addressed this …
in many physiological and pathological conditions. The signal transduction pathway
activated by this cytokine is known to be regulated by several intracellular messengers. In
particular, in many systems nitric oxide (NO) has been shown to protect cells from TNF-α-
induced apoptosis. However, whether NO can be generated by the cytokine to down-
regulate its own apoptotic program has never been studied. We have addressed this …
